ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion
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چکیده
منابع مشابه
Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.
ISG15 is an interferon (IFN)-alpha/beta-induced ubiquitin-like protein that is conjugated to cellular proteins during innate immune responses to viral and bacterial infections. A recent proteomics study identified 158 human proteins targeted for ISG15 conjugation, including the ISG15 E1 and E2 enzymes (Ube1L and UbcH8, respectively) and a HECT E3 enzyme, Herc5. Like the genes encoding Ube1L and...
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The release of retroviruses from cells requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including the ESCRT-III proteins and the Vps4 ATPase. In response to infection, cells have evolved an interferon-induced mechanism to block virus replication through expression of the interferon-stimulated gene 15 (ISG15), a dimer homologue of ubiquitin, which...
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ژورنال
عنوان ژورنال: Clinical & Translational Immunology
سال: 2020
ISSN: 2050-0068,2050-0068
DOI: 10.1002/cti2.1221